相关实验视频

Updated: Feb 19, 2026

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

ICG/MnO-HFn-mPEG-DSPE-Lip增强了ICG光疗的抗癌活性

Dan Ma¹, Huixiang Lu¹, Hai Zhang¹

¹College of Pharmacy, Guizhou University, Guiyang, China.

Lasers in medical science

|May 24, 2025

概括

这项研究开发了新型脂质体,可以克服癌症缺氧,用于光动力学疗法 (PDT). 脂质体通过增加氧气供应来增强治疗结果,提高PDT对肺癌细胞的疗效.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

低氧,低氧状态,显著限制光动力疗法 (PDT) 在癌症治疗中的有效性.
开发克服瘤缺氧的策略对于提高PDT结果至关重要.

研究的目的:

设计和合成封装二氧化 (MnO2),绿色氨酸 (ICG) 和H链氨酸 (HFn) 的PEG化脂质体.
通过一种新的纳米平台来解决缺氧问题并提高PDT的治疗疗效.

主要方法:

使用MnO2用于低氧调节和ICG作为光敏感剂的棒状PEG化脂质体 (ICG/MnO2-HFn-mPEG-DSPE-Lip) 的构建.
脂质体药物载荷,稳定性和安全性的表征.
在模拟瘤条件下测量单个氧量子产量 (Φ_Δ).
使用A549人类肺腺癌细胞进行体外光毒性评估.

主要成果:

脂质体表现出高的药物载荷能力,良好的生物相容性和长期稳定性.
在模拟瘤条件下,单片氧量子产量从0.210 (自由ICG) 显著增加到0.507.
观察到显著的光毒效应,导致A549细胞中90.5%的细胞死亡,而自由ICG则为15%.

结论:

开发的纳米平台提供了一种新的策略,以克服由瘤缺氧引起的PDT耐药性.
增强的疗效归因于由HFn.携带的MnO2介导的氧气供应增加.
这些发现为下一代针对瘤缺氧的治疗系统提供了洞察力.

关键词:

铁素的H链为铁素.氧气过低是因为缺氧.印度氨酸绿色是绿色的脂质体是一种脂质体.照相疗法照相疗法照相疗法

更多相关视频

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...