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rhGALNS在生理缓冲器中的酶稳定性:对持续释放的影响

Samuel Ruesing1, Samuel Stealey1, Qi Gan2

  • 1Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd, St. Louis, MO, 63103, USA.

Applied biochemistry and biotechnology
|May 24, 2025
PubMed
概括

聚乙烯甘醇水凝可以稳定酶N-乙甲胺-6-硫酸盐硫酶 (GALNS),用于治疗Morquio A综合征. 与缓冲溶液相比,在水凝内封装提高了酶稳定性,使潜在的持续释放疗法成为可能.

关键词:
药物交付是药物交付的过程.酶替代疗法是一种酶替代疗法.溶酶体储存障碍 溶酶体储存障碍莫尔基奥一个A.聚乙烯糖水凝是聚乙烯糖的水凝.

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