在双相情感障碍中过渡到euthymia期间跟踪完整血清衍生指数:一项纵向研究
Onur Gökçen1, Kader Semra Karataş1, Merve Akkuş1
1Department of Psychiatry, Kutahya Health Sciences University, Kutahya, Turkey.
Biomarkers in medicine
|May 24, 2025
概括
血液测试中的炎症标志物随着双相情绪障碍患者从情绪发作中恢复而显著变化. 这些与CBC相关的指数为监测双相情感障碍进展提供了潜在的可能性.
科学领域:
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 双极性障碍 (BD) 的特点是情绪发作,炎症与其病理生理学有关.
- 在情绪情节缓解期间炎症标志物的变化尚未完全理解.
研究的目的:
- 为了调查从情绪发作转变为euthymic状态期间住院双相情绪障碍患者的全血清 (CBC) 相关炎症指数的变化.
- 在BD中纵向评估新的炎症指数,如AISI,dNLR,EMR和ENR.
主要方法:
- 一项纵向研究评估了94名住院的BD患者 (58名躁狂患者,36名抑郁患者) 在急性发作期间和退院后的一个月内.
- 在两个评估点评估了CBC,YMRS,HDRS-17和CGI.
- 应用了统计分析,包括邦费罗尼校正,以确定重大变化.
主要成果:
- 观察到白细胞 (WBC) 计数,中性粒细胞,血小板,中性粒细胞与淋巴细胞比率 (NLR),系统性炎症总指数 (AISI),衍生中性粒细胞与淋巴细胞比率 (dNLR),全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI) 的显著下降.
- 氨基酸,氨基酸与单细胞的比率 (EMR) 和氨基酸与中性细胞的比率 (ENR) 显著增加.
- 在邦费罗尼校正后,白血球,中性粒细胞,AISI,SII,SIRI,EMR和ENR的变化仍然显著.
- 在使用酸 (VPA) 的人和不使用者之间注意到了差异.
结论:
- 在BD患者过渡到euthymia期间,CBC衍生的炎症指数发生了明显的变化.
- 这项研究是第一个在 BD 中纵向检查 AISI,dNLR,EMR 和 ENR 的研究.
- 来自CBC的炎症指数显示出作为监测双相情感障碍临床进展的工具的希望.
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