比菲多细菌可以缓解狼性炎,并调节淋巴细胞子集的异常分化
Lihua Wu1,2, Zhirong Guan1, Xiaoyu Zhang1
1School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Rheumatology (Oxford, England)
|May 24, 2025
概括
狼性炎 (LN) 患者的双杆菌缺乏与免疫失衡和损伤相关. 在小鼠中补充Bifidobacterium,其代谢物和短链脂肪酸 (SCFA) 改善了脏健康并恢复了免疫细胞平衡.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 肠道微生物群在狼性炎 (LN) 的发病过程中起着至关重要的作用.
- 益生菌,如Bifidobacterium,正在被探索为潜在的治疗药物对自身免疫性疾病.
- 肠道微生物组合的变化与系统性红斑狼 (SLE) 的免疫失调有关.
研究的目的:
- 调查Bifidobacterium在LN病变发生中的作用.
- 分析Bifidobacterium对LN免疫细胞群的影响.
- 评估Bifidobacterium,其代谢物和短链脂肪酸 (SCFA) 在LN.的小鼠模型中的治疗潜力.
主要方法:
- 在SLE患者的肠道微生物群组成和免疫细胞子集 (CD4+ T细胞,B细胞) 的分析,使用16S rRNA测序和流细胞计.
- 通过ELISA对细胞因子分泌和自身抗体的量化.
- 在用Bifidobacterium,其代谢物和SCFA治疗的MRL/lpr小鼠中评估损伤和免疫细胞恢复.通过组织病理学和免疫光学.
主要成果:
- 患有SLE的患者表现出肠道微生物群多样性减少和Bifidobacterium丰富度.
- 在LN患者中,CD4+ T细胞和B细胞子集发生变化,调控性T细胞 (Tregs) 减少,效能记忆T细胞,Th1和Th17细胞增加.
- 在小鼠中用Bifidobacterium,其代谢物和SCFA治疗改善了损伤,减少了自身抗体,并恢复了免疫细胞平衡.
结论:
- 双杆菌缺乏与SLE患者的免疫失调和损伤有关.
- 补充Bifidobacterium,其代谢物和SCFA证明了通过改善病理和免疫平衡来改善LN的治疗潜力.
更多相关视频
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
3.4K
08:01Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
Published on: November 4, 2016
12.9K
相关概念视频
01:24B Cell Activation and Differentiation
16.1K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
16.1K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
495
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
495
01:24T Cell Types and Functions
2.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.2K