埃斯基塔洛普拉姆有助于动物的瘤生长和转移:它安全吗?
Yosi Azan1, Adam Margalit2, Gal Wiener2
1School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel; Department of Education and Psychology, The Open University, Ra'anana, Israel.
Neoplasia (New York, N.Y.)
|May 24, 2025
概括
作为一种血清素再吸收抑制剂 (SSRI) 的ESCITALOPRAM在外科手术期间使用可能会加速癌症的生长和转移. 这项研究发现,埃斯基塔洛普拉姆在动物模型中持续增加瘤生长和扩散,这引起了癌症患者的担忧.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 癌症研究 癌症研究
背景情况:
- 血清素再吸收抑制剂 (SSRI) 经常被处方给癌症患者进行术前治疗焦虑和抑郁症.
- 新出现的证据表明,SSRI使用可能会影响长期的癌症结果,但术后使用的临床数据有限.
- 埃斯基塔洛普拉姆是瘤学人群中常见的SSRI.
研究的目的:
- 在临床前癌症模型中研究埃斯基塔洛普拉姆对原发性瘤生长和转移的体外和体内影响.
- 评估在接受手术和/或癌症进展的免疫能力强的动物中使用埃斯基塔洛普拉姆的影响.
主要方法:
- 用于胰腺 (Panc02),乳腺 (MADB106, 4T1, EO771) 和结肠 (CT26) 癌症的综合性动物模型.
- 通过各种途径 (腹腔内注射,透,饮用水) 给药埃斯基塔洛普拉姆 (10-15mg/kg/天,持续14-30天).
- 使用生物发光成像评估初级瘤生长,量化实验和自发转移.
主要成果:
- 在体外,埃斯基塔洛普拉姆对癌细胞增殖产生了可变的影响,往往增加或没有影响.
- 在体内,埃斯基塔洛普拉姆在所有测试模型中始终促进了原发性瘤的生长 (增加1.4-2.2倍).
- 埃斯基塔洛普拉姆显著增强了多种癌症类型的实验性和自发性转移 (增加1.6-2.3倍).
结论:
- 在体内给予埃斯基塔洛普拉姆,在临床前癌症模型中显著增加了原发性瘤生长和转移.
- 这些发现引发了人们对在癌症患者中广泛使用埃斯基塔洛普拉姆的术后使用的担忧.
- 需要进一步的研究来阐明体内机制,并评估临床瘤风险.
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