赫迪奥蒂斯 (Hedyotis chrysotricha) 水性提取物通过肝细胞核因子4α调节抑制B型肝炎表面抗原和病毒复制

Yina Yu1, Haoyang Hu1, Yichun Zhang1

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Disease, and National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, PR China.

概括

黑花的水性提取物 (HCM) 有效地抑制乙型肝炎病毒 (HBV) 的复制和转录. 它的机制涉及激活PI3K-AKT和MAPK-ERK1/2通路,抑制HNF4α活性以对抗慢性HBV感染.

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