初潮时的年龄与抑郁症之间的关联:系统性审查和元分析与元回归
Erfan Ghadirzadeh1, Mahmood Moosazadeh2, Kiarash Shakeriastani3
1Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Gastrointestinal Cancer Research Center, Non-Communicable Disease Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Clinics (Sao Paulo, Brazil)
|May 24, 2025
概括
早期初潮,即第一个月经期,与更高的抑郁症风险有关. 这一系统性审查和元分析澄清了Age At Menarche (AAM) 和女性抑郁症之间的联系.
科学领域:
- 生殖健康 生殖健康
- 心理健康 心理健康
- 流行病学 流行病学
背景情况:
- 关于Age At Menarche (AAM) 和抑郁症之间的关系存在相互矛盾的发现.
- 需要进行系统审查和元分析来澄清这种关联.
研究的目的:
- 评估当前关于AAM和抑郁症之间关联的证据.
- 综合多项研究的发现,以更好地了解AAM与抑郁症的联系.
主要方法:
- 从2000年到2024年6月,对Medline,Scopus,Embase,Web of Science和谷歌学者进行了系统的搜索.
- 包括的研究是横截面,病例控制和队列研究,使用纽卡斯尔-太华尺度 (NOS) 评估质量.
- 几率比率 (OR) 和95%信心区间 (95% CI) 使用随机效应模型计算.
主要成果:
- 包括13项研究,包括434,838名参与者.
- 与规范性AAM相比,早期初潮与更高的抑郁症几率显著相关 (OR = 1.36,95% CI: 1.20-1.53).
- 早期初潮也与较晚的AAM相比,抑郁症的几率更高 (OR = 1.52,95% CI 1.22-1.90).
结论:
- 早期初潮与显著增加抑郁症的几率有关.
- 这一发现在与规范性和晚期月经期相比时是正确的.
- 这项研究阐明了初潮早期和抑郁症风险增加之间的联系.
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