韩国猫科冠状病毒的分子特征,2016-2023年
Sung-Hee Kim1, Kyoung-Ki Lee1, Ilseob Lee1
1Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea.
概括
猫科冠状病毒 (FCoV) 影响着韩国30%以上的猫,猫科传染性腹膜炎病毒 (FIPV) 和猫科肠道冠状病毒 (FECV) 菌株都在流传. 遗传分析显示,I型FCoV占主导地位,为当前的韩国猫健康提供了洞察力.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 猫类传染病 猫类传染病
背景情况:
- 猫科冠状病毒 (FCoV) 是家猫中广泛存在的病原体,存在两种血清型 (I和II) 和两种生物型 (猫科肠道冠状病毒[FECV]和猫科传染性周周炎病毒[FIPV]).
- 了解FCoV的流行率和遗传多样性对于管理猫科动物健康和预防疾病爆发至关重要.
研究的目的:
- 调查目前在韩国流传的FCoV的感染状况和遗传特征.
- 基于S基因测序和植物遗传学分析分析FCoV菌株的遗传多样性.
主要方法:
- 韩国925只猫的便样本从2016年到2023年进行了FCoV检测.
- 阳性样本经过了FIPV或FECV的诊断确认.
- 来自24例FCoV阳性病例的部分S基因被测序,重点关注S2亚单元.
主要成果:
- 在抽样的猫中,FCoV被检测到31.8% (294/925) 的猫.
- 在被诊断的病例中,FIPV占47.9%,FECV占52.1%.
- 在测序的S基因中,I型FCoV占主导 (91.7%),II型占8.3%. 一个独特的删除在I型菌株中被发现.
结论:
- 在韩国猫群中,FCoV仍然非常普遍,FIPV和FECV两种生物型都在活跃循环.
- 根据S基因分析,I型FCoV是韩国主要的血清型.
- 这项研究提供了关于韩国FCoV流行病学和分子多样性的基本最新数据.
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