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Updated: Jan 18, 2026

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端粒酶通过合理设计的化蛋白解以奇米拉为目标,通过逆转录酶降解

Grant B Frost1, Yue Liu2, Stephen J Kron2

  • 1Department of Chemistry, Northwestern University, Evanston, IL 60208, United States of America.

Bioorganic & medicinal chemistry letters
|May 24, 2025
PubMed
概括

这项研究介绍了NU-PRO-1,一种新型的蛋白质分解向化母 (PROTAC),可以降解癌细胞中的端粒酶逆转录酶 (TERT). 这种方法可以克服当前癌症治疗中的端粒酶抑制剂的局限性.

关键词:
协同抑制剂 协同抑制剂对DNA损伤的反应反应降解器降解器降解器这就是为什么 TERTTT.泰隆玛酶的使用方法癌症 癌症 癌症 癌症 癌症

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