怀孕期间抗高血压治疗的坚持,按种族和民族分类
Elyse DiCesare1, Krista F Huybrechts1, Brian T Bateman2
1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
American journal of obstetrics and gynecology
|May 24, 2025
概括
与白人患者相比,黑人怀孕患者对抗高血压药物的坚持明显较低. 改善药物坚持对于减少妊娠并发症的种族差异至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 健康差距 研究 研究 研究 研究
背景情况:
- 怀孕期间的慢性高血压增加了对母亲和新生儿不良结果的风险.
- 黑人个人不成比例地经历高血压相关的怀孕发病率.
- 在怀孕之外,在服用抗高血压药物方面存在种族和民族差异.
研究的目的:
- 根据种族和种族来评估怀孕期间抗高血压药物治疗坚持的差异.
- 确定潜在的策略,以减少与高血压相关的不良妊娠结果的种族差异.
主要方法:
- 全国范围的队列研究 (2000 - 2018) 公共保险的孕妇开始推的抗高血压药物.
- 坚持定义为>80%的怀孕后半年所覆盖的天数.
- 逻辑-二项式和二项式回归用于估计风险比率和差异,并对混因素进行调整.
主要成果:
- 与其他群体 (27.2%-28.2%) 相比,黑人个人 (16.8%) 的坚持程度要低得多.
- 经过调整后的分析显示,黑人与白人之间的坚持率较低 (RR=0.59).
- 与白人个人相比,西班牙裔/拉丁裔和其他/未知种族/种族群体的坚持率也较低.
结论:
- 怀孕期间抗高血压治疗的坚持因种族和种族而异.
- 黑人个体的遵守率较低令人担忧,因为他们患不良妊娠结果的风险更高.
- 改善抗高血压药物治疗的策略对于减少孕产妇发病率差异至关重要.
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