鱼油通过GPR120-VEGFR3-MLCK通路促进乳腺结合拉链,减少肠道脂肪的吸收
Junfeng Wang1, Liling Cai1, Jinhao Liu1
1Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry and State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, PR China.
Journal of advanced research
|May 24, 2025
概括
富含DHA和EPA等omega-3脂肪酸的鱼油通过减少脂肪吸收来对抗肥胖. 它通过通过GPR120-VEGFR3-MLCK通路促进乳母细胞中类似拉链的结节来实现这一目标.
科学领域:
- * 营养科学 营养科学
- * 分子生物学 * 分子生物学
- *生理学 *生理学
背景情况:
- *饮食引起的肥胖是一个日益严重的健康问题,与过度的肠道脂肪吸收有关.
- *鱼油含有丰富的omega-3多不和脂肪酸 (PUFA),如多和酸 (DHA) 和乙和酸 (EPA),显示了体重管理的潜力.
- * 鱼油影响肠道脂肪吸收并发挥抗肥胖作用的确切机制在很大程度上仍未被探索.
研究的目的:
- *阐明鱼油抗肥胖作用背后的分子机制.
- * 调查鱼油,DHA和EPA在调节肠道脂肪吸收中的作用.
- * 确定鱼油对肠道淋巴功能影响的特定信号通路.
主要方法:
- * 给高脂肪饮食 (HFD) 养的小鼠服用鱼油,以评估其对肠道脂肪吸收和乳腺结合形态的影响.
- * 淋巴内皮细胞 (LECs) 在体外用DHA或EPA进行治疗,以研究它们对G蛋白结合受体120 (GPR120),血管内皮生长因子受体3 (VEGFR3) 和肌轻链激酶 (MLCK) 信号传导的影响.
- *评估的关键参数包括肠道脂肪吸收,乳牛肉状结的比例,以及VEGFR3和MLCK的表达水平.
主要成果:
- * HFD养小鼠的鱼油补充剂显著抑制了肠道脂肪吸收,与乳类拉链状结节的比例增加和腹中VEGFR3表达的减少相关.
- *体外研究表明,DHA和EPA对LEC的处理通过降低VEGFR3信号的调节来增加类似拉链的接口,这一过程取决于GPR120的激活.
- * 该机制涉及DHA和EPA以GPR120-VEGFR3依赖的方式抑制MLCK信号传递,最终促进乳腺结节的拉链并减少脂肪吸收.
结论:
- *鱼油有效地减少肠道脂肪的吸收,并通过促进乳腺结节的拉链,打击肥胖.
- * GPR120-VEGFR3-MLCK信号通路是鱼油抗肥胖作用的关键媒介.
- *这些发现为鱼油对代谢健康的有益影响的分子机制提供了新的见解.
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