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Updated: Jan 18, 2026

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角膜疾病中的微RNA:作为生物标志物,调节剂和治疗药物的新兴作用

Liangbo Chen¹, Shiding Li¹, Yao Fu¹

¹Department of Ophthalmology, Shanghai Ninth People's Hospill, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 200011, Shanghai, China.

The ocular surface

|May 24, 2025

概括

微RNAs (miRNAs) 是角膜疾病的关键调节者,影响愈合和炎症. 本综述探讨了它们对眼部疾病的诊断和治疗潜力.

科学领域:

眼科医生眼科眼科
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

微RNAs (miRNAs) 是简短的,非编码的RNAs调节基因表达.
miRNAs与角膜病理生理学有关,包括伤口愈合,炎症和新血管化.

研究的目的:

审查近期对角膜疾病miRNA研究的进展.
专注于诊断生物标志物,细胞调节和角膜中miRNAs的治疗应用.

主要方法:

关于角膜疾病中miRNAs当前研究的文献综述.
分析miRNA检测技术及其诊断潜力.
角膜细胞生物学和治疗策略中的miRNA机制的概述.

主要成果:

miRNAs在诸如眼和外体细胞样本中的诊断生物标志物中表现有前途.
miRNAs调节角膜细胞中的关键生物过程.
基于miRNA的疗法具有潜力,但临床翻译面临挑战.

结论:

miRNAs在角膜疾病的发病过程中至关重要,并具有重要的诊断和治疗潜力.
需要进一步的研究才能充分实现miRNA在治疗角膜疾病中的应用.
检测和传递系统的进步是临床翻译的关键.

关键词:

生物标志物生物标志物角质细胞疾病角质细胞疾病监管机构监管机构它具有治疗性的作用.在 miRNA 递送过程中, miRNA 递送这是一个微型RNA.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...