在年轻成年人中,抑郁症和神经对奖励和惩罚的反应的多基因风险
Yu Chen1, Huey-Ting Li2, Xingguang Luo1
1Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
概括
抑郁症的遗传风险会影响奖励和惩罚任务期间的大脑活动. 这项研究揭示了抑郁症多基因风险评分 (PRS) 与神经反应的相关性,为抑郁症标志物提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 抑郁症与奖励和惩罚处理的改变有关.
- 遗传因素有助于抑郁症的风险.
- 遗传性抑郁风险对奖励/惩罚神经反应的影响尚未得到充分理解.
研究的目的:
- 调查抑郁症遗传风险与神经对奖励和惩罚反应之间的关联.
- 探索抑郁症的多基因风险得分 (PRS) 与博任务期间的大脑活动的关系.
主要方法:
- 利用了 879 名年轻成年人通过 fMRI 执行博任务的人类连接体项目的数据.
- 评估了抑郁症的严重程度,并计算了抑郁症的多基因风险得分 (PRS).
- 进行了线性回归来分析大脑对奖励/惩罚的反应,与抑郁症得分和PRS相关.
主要成果:
- 在奖励和惩罚处理过程中,广泛的额头,头顶和尾皮质激活与PRS负相关.
- 后侧环状皮层的激活与PRS相关的惩罚处理特别相关.
- 在与PRS相关的奖励和惩罚的神经反应中观察到性别差异.
结论:
- 抑郁症的遗传风险显著影响奖励和惩罚的神经处理.
- 研究结果表明,抑郁症的基因标志物具有基因信息.
- 突出了遗传倾向在情感处理中的作用.
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