骨是转移性甲基荷兰胺分泌瘤的双重受害者
Arnaud Jannin1, Marie-Hélène Vieillard2, George Lion3
1Université de Lille, CNRS, Inserm, CHU de Lille, UMR9020-U1277, Cancer Heterogeneity Plasticity and Resistance to Therapies (CANTHER), 59000 Lille, France; CHU de Lille, Department of Endocrinology, Diabetology, and Metabolism, 59000 Lille, France.
Annales d'endocrinologie
|May 24, 2025
概括
转移性骨红细胞瘤和副骨瘤 (PPGL) 可以严重影响骨健康,导致骨质疏松症和骨折. 早期识别这些骨并发症对于管理转移PPGL的患者至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 良性分泌甲基荷氨酸的乳红细胞瘤和偏角质瘤 (PPGL) 可以导致二次骨质疏松症.
- 转移性PPGLs经常存在骨转移和高甲基荷胺水平,可能导致更严重的骨损伤.
研究的目的:
- 在长期随访期间调查转移PPGL患者的骨密度和骨质量.
- 了解与转移性PPGL相关的骨并发症.
主要方法:
- 关于三名转移PPGL患者的案例研究 (两名患有横瘤,一名患有色细胞瘤).
- 骨矿物质密度 (BMD) 和质量通过使用双能X射线吸收度 (DXA) 和轨道骨评分 (TBS) 进行评估.
- 高分辨率的外围定量计算断层扫描 (HR-pQCT) 用于一个患者.
主要成果:
- 两名患有横瘤的患者表现出腰部和部骨质疏松症.
- 一名患者患有骨质疏松和转移性脊椎骨折,并减少了TBS.
- 另一名患者显示,尽管没有脊椎骨折,但骨骨和放射性脊椎骨的厚度减少了.
结论:
- 转移性PPGL的骨密度和质量受损与长期的多余类甲基荷胺有关.
- 这些骨并发症有助于转移PPGL的骨相关事件.
- 对于转移PPGL的患者来说,识别和管理骨健康是很重要的.
相关概念视频
Blood and Nerve Supply to the Bones
10.8K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.8K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K


