挪威中部缺血性中风后的主要心血管事件和全因死亡率 - 一项为期三年的前性多中心研究
Ailan Phan1, Bent Indredavik2, Stian Lydersen3
1Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Norway.
概括
长期中风结果显示,主要心血管事件的发病率为15%,三年内死亡率为18%. 降低心脏病风险和中风严重程度可以改善中风患者的生存率.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 由于预防和风险因素管理的改善,心血管疾病发病率有所下降.
- 对首次缺血性中风幸存者的最新长期结果数据有限.
研究的目的:
- 在第一次缺血性中风后三年评估主要心血管事件和全因死亡率.
- 评估可修改的心血管和其他预后因素对中风结果的影响.
主要方法:
- 在MIDNOR STROKE研究中,有787名在挪威中部 (2015-2017年) 首次患有缺血性中风的患者被前性招募.
- 在住院期间收集的数据与国家登记处联系在一起,用于对主要心血管事件和存活率的三年随访.
- 竞争的风险模型,卡普兰-梅尔和考克斯回归分析了心血管事件和全因死亡率.
主要成果:
- 三年内主要心血管事件的累积发病率为15.0%,复发性中风是最常见的.
- 在中风后三年,全因死亡率为18.0%.
- 冠状动脉疾病增加了主要血管事件 (HR: 1.59) 和死亡 (HR: 1.66) 的风险;NIHSS在第一天预测死亡率 (HR: 1.08).
结论:
- 脑卒中后的三年生存率高于之前报告的水平,但主要心血管事件的风险仍然很大.
- 大约15%的中风幸存者在三年内经历重大心血管事件.
- 针对降低心脏病风险和尽量减少中风严重性的干预措施对于改善长期中风结果至关重要.
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