当代基于社区的前列腺癌查活动的实用性
Nassib Abou Heidar1, Zhe Jing1, Richard Satterwhite1
1Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Clinical genitourinary cancer
|May 24, 2025
概括
社区前列腺癌 (PCa) 查活动有效地识别出具有临床意义的PCa. 结合PSA测试,DRE和MRI有助于早期检测,查21个重要疾病的数字是必要的.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 早期发现前列腺癌 (PCa) 可能会降低死亡率,但有过度诊断和过度治疗的风险.
- 评估基于社区的PCa早期检测活动对于优化查策略至关重要.
- 在现实环境中评估当代查方法的产量是很重要的.
研究的目的:
- 评估基于社区的前列腺癌早期检测活动的有效性.
- 评估PSA测试,数字直肠检查 (DRE) 和多参数MRI (mpMRI) 的联合诊断产量.
- 确定与诊断临床显著PCa (csPCa) 相关的因素.
主要方法:
- 19个PCa早期检测活动 (2015-2023) 的回顾性审查.
- 包括所有参与者的PSA测试和DRE,以及风险人群的mpMRI.
- 后勤回归分析以确定与PCa诊断相关的因素.
主要成果:
- 1171名男性进行了查;7.4%接受了活检,76%被诊断患有PCa (86% csPCa).
- 较高的PSA水平和可疑的DRE发现与csPCa诊断有显著的关联.
- 诊断1 csPCa所需查的数量为21 (95% CI 16-27).
结论:
- 结合PSA,DRE和MRI的当代PCa查活动可以有效检测csPCa.
- 谨慎使用前列腺MRI和活检可以提高查程序的诊断准确性.
- 这些运动表明,早期检测和避免过度诊断之间存在着有利的平衡.
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