孤立的四肢输液/输液用于不可切割的面黑色素瘤与非面黑色素瘤在传输转移的转移
Michelle M Dugan1, Jacob Israeli2, Nicholas Chin2
1Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Annals of surgical oncology
|May 24, 2025
概括
与其他黑色素瘤相比,Acral lentiginous黑色素瘤 (ALM) 显示出与孤立四肢输液/输液 (ILI/ILP) 相似的局部控制. 然而,ALM的生存结果较差,这表明需要与ILI/ILP一起改善全身疗法.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 皮肤病学 皮肤病学
背景情况:
- 与非ALM亚型相比,Acral lentiginous黑色素瘤 (ALM) 的预后较差,遗传特征不明,限制了治疗选择.
- 本研究研究了在被诊断为ALM的患者和非ALM的患者中,孤立四肢输注或 perfusion (ILI/ILP) 的比较结果.
研究的目的:
- 为了比较ILI/ILP在治疗状状黑色素瘤 (ALM) 和非ALM的疗效.
- 为了评估ALM和非ALM患者之间的局部区域疾病控制和生存结果,用ILI/ILP治疗.
主要方法:
- 进行了多机构的回顾性审查.
- 包括2002年至2023年期间接受ILI/ILP治疗的无法切除的黑色素瘤过境转移 (ITM) 患者.
- 分析了364名患者 (84名ALM,280名非ALM) 的数据.
主要成果:
- 与非ALM相比,ALM瘤表现出更大的布雷斯洛厚度和.
- 在ALM和非ALM组之间的完整或总体响应率中没有发现显著差异.
- 虽然现场无进展生存 (PFS) 和总生存率相似,但ALM显示现场外PFS和疾病特异性生存率明显较短.
结论:
- 隔离四肢输液或输液 (ILI/ILP) 实现了对ALM和非ALM中转移转移的可比的局部区域疾病控制.
- 在ALM患者中较差的疾病特异性存活率和外场PFS表明瘤生物学更具侵略性.
- 这些发现强调了系统疗法与ILI/ILP结合的潜在作用,以加强ALM的局部和远程疾病控制.
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