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在一般人群中通过饮食暴露于肌酸前体氨基酸

David Nedeljkovic¹, Sergej M Ostojic^2,3,4

¹Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia.

|May 24, 2025

概括

内生肌酸合成显著超过美国人口的饮食摄入量,突出显示了前体氨基酸如甘氨酸,氨酸和氨酸对肌酸可用性的重要性. 老年人可能由于前体可用性下降而降低了肌酸水平.

科学领域:

营养科学营养科学
代谢生物化学代谢生物化学

背景情况:

肌酸对于能量代谢至关重要,饮食和内部合成都有助于其可用性.
虽然饮食中的肌酸得到了充分的研究,但前体氨基酸 (甘氨酸,氨酸,氨酸) 在内源合成中的作用不明.
这项研究调查了前体氨基酸摄入量及其对美国人口肌酸合成的贡献.

研究的目的:

为了评估美国儿童和成人饮食中摄入的肌酸前体氨基酸的摄入量.
为了比较内源性肌酸合成与直接饮食摄入的肌酸.
为了评估不同年龄组的肌酸总可用性.

主要方法:

在第三次全国健康和营养检查调查 (NHANES III) 中,分析了29945名参与者 (年龄≥2岁) 的饮食回忆数据.
计算每公斤体重的甘氨酸,氨酸,氨酸和肌酸摄入量.
使用已确定的前体氨基酸代谢转化因子对内源性肌酸合成的估计.

主要成果:

平均每日摄入量:甘氨酸 (59.6毫克/公斤),氨酸 (77.2毫克/公斤),氨酸 (31.9毫克/公斤) 和肌酸 (15.5毫克/公斤).
估计的内源性肌酸合成 (41.9 mg/kg/天) 显著更高 (大约为1.9 mg/kg/天). 在所有年龄组中,食直接摄入的肌酸比直接摄入的肌酸多2.7倍).
肌酸前体的可用性随着年龄的增长而下降,65岁及以上的个体的水平最低.

结论:

内生肌酸合成是美国人口肌酸可用性的主要来源,超过了饮食摄入量.
肌酸代谢受到前体氨基酸的可用性显著影响.
老年人可能面临较高的肌酸可用性降低的风险,这需要进一步调查和潜在的干预措施.

关键词:

氨基酸是氨基酸的组成部分.肌酸蛋白是什么意思肌酸蛋白是什么意思代谢过程中的代谢.尼汉斯 (NHANES) 是一个名人.营养营养营养营养营养这是一个前身的前身.

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