脉冲压,白质超强度和认知:在成年人一生中的调解效应
Jade Hannan1, Sarah Newman-Norlund1, Natalie Busby1
1Department of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Annals of clinical and translational neurology
|May 25, 2025
概括
脉压,而不是平均动脉压,将年龄与白质超强度联系起来. 白质超强度也会影响成年人的认知分数.
科学领域:
- 神经成像是一种神经成像.
- 心血管健康 心血管健康
- 认知老龄化 认知老龄化
背景情况:
- 白质超强度 (WMH) 与衰老和认知能力下降有关.
- 调解这种关系的特定血压参数尚未完全理解.
研究的目的:
- 要确定脉冲压或平均动脉压是否介导了年龄和WMH之间的联系.
- 研究WMH作为老年人认知功能的调解者.
主要方法:
- 从老化大脑队列研究中对231名没有中风和痴呆症的成年人进行了回顾性分析.
- 在T2-FLAIRMRI扫描上使用深度学习量化WMH负载.
- 调解分析以评估脉冲压,平均动脉压和WMH在与年龄相关的认知变化中的作用.
主要成果:
- 脉压显著调解了年龄和WMH负载之间的关系.
- 平均动脉压没有显著的调节效应.
- WMH负载部分调解了年龄和认知得分之间的关联 (蒙特利尔认知评估).
结论:
- 脉压,而不是平均动脉压,与与年龄相关的WMH积累有机械联系.
- 在成年人一生中,WMH负载会调解认知衰退.
- 控制脉压对于保持大脑健康和老化中的认知功能至关重要.
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