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儿科侧侧偏远大腿骨参考范围为1至18岁的儿童

Babette S Zemel¹, John A Shepherd², Laila Kazemi²

¹Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

|May 25, 2025

概括

这项研究为1至18岁儿童的侧面远骨提供了关键的骨矿物质密度 (BMD) 参考范围. 这些范围有助于评估患有肌肉骨疾病的儿童的骨折风险,并解释生长变化.

科学领域:

儿科内分泌学儿科内分泌学
肌肉骨健康肌肉骨健康
骨密度测试骨密度测试骨密度测试

背景情况:

患有肌肉骨疾病的儿童面临高骨折风险.
侧偏远大腿骨 (LDF) 是使用双能量X射线吸收计 (DXA) 测量骨矿物质密度 (BMD) 的关键部位.
确定LDF BMD的儿科参考范围和增长调整的指标对于准确的临床解释至关重要.

研究的目的:

在1至18岁儿童中制定LDF BMD的平滑参考范围.
创建基于身高的BMD调整的预测方程.
加强对患有肌肉骨疾病的儿童骨健康的评估.

主要方法:

双能X射线吸收仪 (DXA) 对1245名儿童 (1-18岁) 进行了LDF扫描.
在较小的儿童中,使用重复扫描来评估精度.
为三个LDF BMD区域生成了平滑的参考范围,并开发了预测方程以考虑身高变化.

主要成果:

收集了2400多个LDF BMD测量结果,为三个地区提供了参考范围.
骨部位的精度与其他骨部位 (1.33-2.42% CV) 相当.
在年龄较大时,女性的BMD比男性高;黑人儿童的BMD比非黑人儿童高.
高度与年龄相对应的Z分数与前期和前期青春期儿童的BMD与年龄相对应的Z分数相关,导致调整方程的发展.

结论:

这项研究确定了儿童 (1-18岁) LDF BMD 的重要平滑参考范围,解决了儿科骨健康评估中的差距.
开发的方程有助于估计身体尺寸对 BMD-for-age Z-score 的影响.
这些发现支持对患有肌肉骨疾病的儿童进行更好的骨折风险评估.

关键词:

骨矿物质密度骨矿物质密度孩子孩子孩子孩子侧侧的远距离大腿骨.

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