药用大麻在焦虑症管理中的作用:系统性审查
Leah Roberts1, Elizabeth Sorial2, Charley A Budgeon3
1School of Population and Global Health, 35 Stirling Hwy, Crawley WA 6009, Australia; NHMRC Centre of Research Excellence in Medicines Intelligence, University of South Australia, University of New South Wales, University of Sydney, University of Western Australia, Australia.
Psychiatry research
|May 25, 2025
概括
药用大麻显示出缓解焦虑的希望,许多研究报告了积极的结果. 然而,需要更多高质量的研究来确认长期益处和焦虑障碍的最佳剂量.
科学领域:
- 精神病学和行为科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 焦虑障碍的诊断正在增加,促使人们对传统治疗方法的替代品产生兴趣.
- 医用大麻正在被探索为潜在的替代药物治疗焦虑相关疾病.
研究的目的:
- 系统地审查基于大麻的干预措施对焦虑相关疾病的有效性和有效性.
- 检查各种大麻制剂和治疗焦虑的干预措施.
主要方法:
- 在MEDLINE,EMBASE,CINAHL和PsycInfo (2023年10月至12月) 搜索同行评审的实证研究.
- 包括对被诊断患有焦虑障碍的成年人 (18+) 的研究,不包括案例系列,案例研究和评论.
- 使用MASTER和Qualsyst工具评估偏差风险.
主要成果:
- 57项研究符合纳入标准,各种设计包括队列和随机对照试验.
- 由于报告不充分,人们注意到存在偏差的高风险;然而,70%的最高质量的研究报告了对GAD,SAD和PTSD的积极改善.
- 超过90%的所有研究表明CBD和THC类大麻的结果是积极的,尽管剂量信息往往缺失或自我报告.
结论:
- 医用大麻显示出减少焦虑症状的潜力.
- 长期益处和对生活质量的影响需要进一步研究.
- 高质量的纵向研究与标准化剂量是必不可少的.
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