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大动脉周血管脂肪组织体积的种族差异及其与中年男性动脉硬的相关性

Akira Sekikawa¹, Mengyi Li¹, Michel Clifton¹

¹Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Atherosclerosis

|May 25, 2025

概括

非洲裔美国人比白人美国人少有大动脉周血管脂肪组织 (aPVAT),主要是由于内脏脂肪组织 (VAT) 的差异. aPVAT与不同种族的动脉硬性有关,这表明它在心血管健康方面发挥了作用.

科学领域:

心血管科学心血管科学
脂肪组织生物学脂肪组织生物学
种族健康差异的差异

背景情况:

宫外脂肪,如大动脉周血管脂肪组织 (aPVAT),影响心血管健康.
非洲血统的个人表现出较低的宫外脂肪水平比欧洲血统的个人.
在aPVAT的种族差异及其与动脉硬的联系还不清楚.

研究的目的:

为了调查男性在PVAT量中的种族差异.
为了检查aPVAT和动脉硬性 (心骨脉冲波浪速度,cfPWV) 之间的关联.
探索对这些关系的潜在种族特异性影响.

主要方法:

对325名男性 (40-49岁;252名白人,73名非裔美国人) 的横截面研究.
通过电子束计算断层扫描对aPVAT和内脏脂肪组织 (VAT) 的量化.
动脉硬度的评估使用带 - 骨脉冲波速率 (cfPWV).
多变量回归分析经过调整以考虑混因素,包括BMI和VAT.

主要成果:

非洲裔美国人的PVAT量明显低于白人美国人 (42.7厘米3比49.1厘米3).
这一差异在调整为增值税后并不显著.
aPVAT与cfPWV正相关,独立于增值税和BMI (p=0.04).
对于aPVAT和cfPWV没有观察到重要的种族特异性相互作用.

结论:

与白人相比,非洲裔美国人的PVAT较低主要是由增值税差异解释的.
aPVAT与动脉硬之间的关联在不同种族群体中显而易见.
需要进一步的纵向研究来阐明因果关系和机制.

关键词:

大动脉周围血管脂肪组织 (aPVAT)动脉的硬性动脉的硬性带 - 关节脉冲脉冲波的速度波速.宫外脂肪是什么意思宫外脂肪是什么意思种族差异是种族的差异.内脏脂肪组织的脂肪组织.

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