对口腔腔状细胞癌 (OCSCC) 患者的生存结果和复发模式进行比较,这些患者接受了辅助或绝对 (化疗) 放射治疗的治疗意图
K Oguejiofor1, S Ramkumar1, A-A Nabi2
1Department of Clinical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
概括
与最终治疗相比,激进手术后辅助 (化疗) 放射治疗改善了局部晚期口腔状细胞癌 (LA-OCSCC) 的生存结果. 对于LA-OCSCC的复发模式是积极的,强调了治疗性手术对于更好的生存率的重要性.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 局部发达的口腔状细胞癌 (LA-OCSCC) 是一个重要的治疗挑战.
- 治疗策略通常涉及彻底的手术,其次是辅助疗法或最终的 (化疗) 放射治疗.
研究的目的:
- 为了比较LA-OCSCC患者的生存结果和复发模式.
- 为了评估激进手术与辅助性 (化疗) 放射治疗与最终 (化疗) 放射治疗的疗效.
主要方法:
- 在2012-2022年间,对LA-OCSCC患者进行了以治疗意图治疗的回顾性分析.
- 对接受术后辅助 (化疗) 放射治疗和接受最终 (化疗) 放射治疗的患者之间的结局进行比较.
- 排除在辅助治疗开始前复发的患者.
主要成果:
- 接受辅助 (化疗) 放射治疗的患者 (n=99) 的平均整体存活期 (61个月) 比最终组 (n=35,43个月) 优于患者.
- 在辅助剂 (17个月) 和最终 (15个月) 组之间,无进展生存时间相似.
- 复发率相似,在前两年内发生率很高,远程复发可能发生而没有局部-区域复发.
结论:
- 激进手术后辅助 (化疗) 放射治疗为手术切除的LA-OCSCC提供了更好的生存结果.
- 绝对的前期 (化疗) 放射治疗与较差的生存结果有关.
- LA-OCSCC复发的攻击性强调了有效的手术管理的关键作用.
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