通过使用omics数据和预测建模,对与衰老相关的干预措施进行in-silico评估
Georg Fuellen1, Daniel Palmer2, Claudia Fruijtier3
1Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany; UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
Ageing research reviews
|May 25, 2025
概括
识别有效的衰老干预措施需要强大的方法. 本研究审查了in-silico方法,优先考虑干预数据,以准确预测寿命延长和安全性评估.
科学领域:
- 衰老的研究研究.
- 计算生物学是一种计算生物学.
- 发现生物标志物的发现.
背景情况:
- 老龄化干预在长期临床评估中面临挑战.
- 使用基于omics的生物标志物的in-silico方法对于预测干预疗效至关重要.
- 目前的预测模型通常在观测数据上训练,可能会产生偏差的结果.
研究的目的:
- 通过计算方法审查和优先考虑评估衰老干预措施的方法.
- 强调使用干预数据,安全评估和标准化基准的重要性.
- 讨论各种特征处理和预测建模技术,包括AI.
主要方法:
- 对老龄化干预措施的现有评估方法的审查.
- 优先训练干预数据上的预测模型,而不是观察数据.
- 探索特征处理,线性/非线性建模,自动化机器学习和人工智能.
主要成果:
- 在干预数据上培训的第一个寿命延长分类器的出现.
- 在预测建模中强调安全性和毒性评估的必要性.
- 讨论用于可靠评估的标准化基准.
结论:
- 可解释和可重现的策略对于计算衰老研究至关重要.
- 整合安全指标和对干预基准的验证对于准确的预测器开发至关重要.
- 未来的方向强调对人工智能驱动的衰老干预预测进行强有力的验证.
相关概念视频
01:19The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
01:26Aging
200
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
200