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聚电解质纳米颗粒来源于杜连种子的,经基托修饰,用于选择性向癌细胞

Jindrayani Nyoo Putro¹, Fasih Bintang Ilhami², Chih-Chia Cheng³

¹Chemical Engineering Master Program, Faculty of Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya 60114, Indonesia; Collaborative Research Center for Sustainable and Zero Waste Industries, Jl. Kalijudan 37, Surabaya 60114, East Java, Indonesia.

International journal of biological macromolecules

|May 25, 2025

概括

研究人员从榴莲种子和奇托中开发了新的纳米粒子. 这些生物相容的纳米粒子显示选择性光用于追踪癌细胞,提供了一个有前途的绿色合成方法.

科学领域:

材料科学材料科学材料科学
生物技术是生物技术.
纳米技术纳米技术

背景情况:

自然的多糖为纳米粒子开发提供生物相容的平台.
素修饰可以增强天然聚合物的特性.
榴莲种子是一种未充分利用的生物材料来源.

研究的目的:

为了合成和表征复杂的纳米颗粒使用榴莲种子改性奇多.
评估开发的纳米粒子的pH响应性行为,稳定性和生物相容性.
为了研究这些纳米粒子通过光追踪癌细胞的潜力.

主要方法:

复杂的纳米粒子形成使用榴莲种子和奇托.
通过H NMR,ZETA潜力,SEM,FTIR,光谱仪进行表征.
评估pH反应性胀,动力稳定性,溶血活性和细胞毒性 (NIH / 3T3和HeLa细胞).

主要成果:

通过H NMR证实了相互透的聚合物网络纳米粒子的成功合成.
证明了pH反应性胀,在酸性pH (2.1) 时的胀比中性 (5.5,7.4) 时的胀更高.
基托桑修饰增强了动力稳定性;纳米颗粒表现出良好的血液兼容性 (4%的溶血活性) 和对HeLa癌细胞的选择性细胞毒性.
观察到强烈的细胞内蓝色光,表明癌细胞跟踪的潜力.

结论:

榴莲种子改性奇托桑纳米颗粒的绿色合成是可行的.
这些纳米粒子表现出理想的特性,包括pH响应性,稳定性,生物相容性和选择性光.
这些纳米粒子在向癌细胞成像和诊断方面表现有前途.

关键词:

生物成像是一种生物成像.基托桑是一种酸盐.细胞毒性细胞毒性榴莲种子的口香糖.聚电解质纳米颗粒的多电解质纳米颗粒.

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