短间隔的半球间抑制并非源于运动热点
David Emanuel Vetter1, Andreas Jooß1, Tuomas P Mutanen2
1Department of Neurology & Stroke, University of Tübingen, Tübingen, Germany; Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
我们发现,短间隔半球间抑制 (SIHI) 源于一个不同的区域,即"冷点",与产生运动唤起潜能 (MEP) 的运动热点分开. 针对这个冷点可以提高SIHI的有效性.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 大脑刺激 大脑刺激
背景情况:
- 配对线圈横磁刺激 (TMS) 揭示了因果大脑连接.
- 短间隔半球间抑制 (SIHI) 是通过体通过原发动皮层 (M1) 之间的快速抑制过程.
- 以前的研究表明,SIHI和运动唤起潜能 (MEP) 来自相同的运动热点,但涉及不同的神经元群体.
研究的目的:
- 使用基于TMS的新关联方法,对SIHI和MEP负责的不同神经元群体进行空间歧视.
- 为了验证SIHI和MEP是否可以被映射到分离皮层起源.
主要方法:
- 在18名健康志愿者中使用基于TMS的关联方法来绘制SIHI和MEP起源的"源空间".
- 将SIHI和MEP的起源映射到每个半球的手肌.
主要成果:
- SIHI的起源,称为"冷点",位于电机热点附近 (手旋,中央),侧向侧向移动约6毫米.
- 与针对电机热点相比,针对冷点显著提高了SIHI.
- 大多数受试者可以识别SIHI的冷点.
结论:
- 基于TMS的关联方法成功地为半球间抑制和运动唤起潜力绘制了独特的神经元群体.
- 通过刺激冷点而不是运动热点来更有效地引起SIHI.
- 这一发现对修改半球间通信有影响,可能有助于中风康复.
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