蛋白质和总糖摄入量调节了rs9939609单核酸多态效应在脂肪质量和肥胖相关基因的身体组成

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Updated: Sep 20, 2025

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Luciana Olmedo¹, Fernando Javier Luna², Hernán Dopazo³

¹Instituto de Investigaciones Bioquímicas de La Plata (CONICET- Facultad de Ciencias Médicas, Universidad Nacional de La Plata), Argentina; Programa de Referencia y Biobanco Genómico de la Población Argentina (PoblAr), Argentina.

Clinical nutrition ESPEN

|May 25, 2025

概括

FTO基因的A基因会影响身体质量指数 (BMI),身体脂肪 (BF),内脏脂肪 (VF) 和骨肌肉 (SM). 蛋白质,糖和脂肪等食因素与该基因相互作用,调节这些效应.

科学领域:

遗传学和营养学
人体生理学人体生理学
肥胖问题研究研究

背景情况:

FTO基因rs9939609 A等位基因与更高的BMI有关.
环境因素可能会改变FTO基因对肥胖的影响.
了解基因饮食相互作用对于个性化肥胖管理至关重要.

研究的目的:

研究影响人体组成的基因营养相互作用.
分析FTO rs9939609 A基因对BMI,内脏脂肪 (VF),骨肌肉 (SM) 和身体脂肪 (BF) 的影响.
确定调节FTO基因对肥胖相关特征的影响的特定饮食成分.

主要方法:

对阿根廷成年人的横截面研究.
通过生物电阻分析评估的身体组成.
饮食摄入量通过使用食物频率问卷进行评估.
使用实时PCR进行的基因定型.
统计分析包括多重线性回归和ANCOVA用于基因饮食相互作用.

主要成果:

FTO rs9939609 A等位基因与增加的BMI,BF和VF显著相关,并减少了SM.
蛋白质,总糖和和脂肪酸 (SFA) 与BMI,BF和VF的显著基因营养相互作用被观察到.
包括牛奶,酸奶,肉类,蛋和水果在内的特定食品群体与BMI和VF显著相互作用.

结论:

FTO rs9939609 A等位基因有助于身体组成的变化.
饮食摄入量显著调节FTO基因对身体组成的影响.
这些发现强调了饮食在控制与特定遗传变异相关的肥胖风险方面的重要性.

关键词:

基因与营养物相互作用拉丁美洲拉丁美洲拉丁美洲营养遗传学营养遗传学肥胖问题肥胖问题蛋白质摄入量蛋白质摄入量

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