在癌症患者的口腔粘膜炎中使用LED低水平光疗法:系统性审查和GRADE分析
Betsy Joseph1, Matti Mauramo2, Timo Sorsa3
1Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
概括
发光二极管 (LED) 治疗在减少癌症患者口腔粘膜炎 (OM) 严重程度和疼痛方面显示出有前途. 然而,证据的确定性较低,需要进一步的研究来证实愈合时间的好处,并建立最佳的方案.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 基于证据的医学基于证据的医学.
背景情况:
- 癌症治疗通常会诱导口腔粘膜炎 (OM),这是一个痛苦的情况.
- 目前对OM的标准护理存在局限性.
- 发光二极管 (LED) 治疗正在作为一种新的治疗方法进行探索.
研究的目的:
- 系统地审查LED疗法对治疗癌症治疗诱导的OM疗法的疗效.
- 评估LED治疗对OM严重程度,疼痛和愈合时间的影响.
- 为了比较LED治疗与标准护理或假光干预.
主要方法:
- 使用相关的MeSH术语和关键词对主要数据库进行系统审查.
- 两位作者对研究进行了独立选.
- 使用 RoB-2 和 ROBINS-I 工具评估偏差风险.
- 使用GRADE方法评估证据确定性.
主要成果:
- 包含了五项研究,包括256名参与者.
- 四项研究报告说,LED治疗显著减少了OM的严重程度和疼痛.
- 一项研究表明,可能会改善愈合时间.
- 发现了中等偏差风险和证据的低确定性.
- 由于数据异质性,元分析是不可行的.
结论:
- 照明灯治疗可以有效地减少疼痛和癌症治疗诱导的OM的持续时间.
- 证据的低确定性凸显了需要高质量,更大规模的纵向研究.
- 需要进一步的研究来确认疗效并确定最佳的治疗方案.
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