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Updated: Sep 20, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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对人类CD39的反义,在炎症性肠道疾病中失调免疫代谢

Lina Zhang1,2, Cortney Cagle1, Du Hanh Nguyen1,3

  • 1Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Cellular & molecular immunology
|May 25, 2025
PubMed
概括

在炎症性肠病 (IBD) 中,缺陷的CD39水平与免疫细胞失衡有关. 在调节性T (Treg) 和T辅助17 (Th17) 细胞中向CD39-ASRNA恢复了免疫平衡,并降低了IBD活动.

关键词:
CD39 反意义的反意义免疫新陈代谢 免疫新陈代谢炎症性肠病是一种炎症性肠病.Th17细胞的细胞.这就是Treg Treg.

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