运动皮层刺激用于耐火三端疼痛:大西洋加拿大的病例系列
Jacob Saucier1,2, Lyndon Boone3, Simon Elsliger2,4
1Division of Neurology, Department of Medicine, Université de Montreal, Montreal, Quebec, Canada.
概括
运动皮层刺激 (MCS) 有效地治疗难治的三角神经病变 (PTN) 疼痛. 这种神经调节技术在耐火病例中显著减少了面部疼痛和阿片类药物的使用.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 疼痛管理 疼痛管理
背景情况:
- 神经调节是一种新兴的治疗难治性疼痛的方法.
- 运动皮层刺激 (MCS) 显示在慢性口腔面部疼痛中具有有效性.
- 疼痛性三角神经病变 (PTN) 在耐火病例中是一个重大挑战.
研究的目的:
- 评估MCS在耐火PTN患者中的有效性.
- 评估MCS植入后的疼痛减轻和阿片类药物消耗.
主要方法:
- 五名耐火PTN患者的回顾性病例系列,接受MCS治疗.
- 测量结果包括视觉模拟尺度 (VAS) 疼痛和吗啡等效剂量 (MED).
- 手术后6个月和12个月的后续评估.
主要成果:
- 所有五名患者都实现了初级 (≥50%的VAS减少) 和二次 (≥60%的MED减少) 结局.
- 平均VAS在MCS后12个月下降了77%.
- 平均MED/天减少了93%,80%的患者在18个月后没有阿片类药物.
结论:
- 在耐火性三角关节疼痛中,MCS显示出长期缓解疼痛的显著潜力.
- MCS可以大大减少阿片类药物消费.
- 进一步的大规模多中心试验是有必要的.
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