溶酶对肠道微生物群的调节作为血管炎症衰老的关键调节剂
Chenyang Zhang1,2, Xin Zhao3, Hang Zhang4,5
1Institute of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Jiangnan University, Wuxi 214122, China.
Research (Washington, D.C.)
|May 26, 2025
概括
酶 (LYZ) 缺乏会加速血管衰老,并改变肠道细菌. 口服LYZ恢复肠道健康并逆转血管衰老,突出LYZ和肠道微生物群-PI3K-Akt轴作为治疗点.
科学领域:
- 生物老龄化 生物老龄化
- 血管生物学 血管生物学
- 微生物组研究 微生物组研究
背景情况:
- 血管炎症衰老与多病症和免疫衰老有关.
- 在依赖年龄的血管疾病中观察到升高的酶 (LYZ) 基因表达.
研究的目的:
- 调查LYZ在血管炎症衰老中的作用.
- 探索肠道微生物群对血管衰老的影响.
- 确定与年龄相关的血管疾病的潜在治疗点.
主要方法:
- 基因表达的生物信息分析.
- 野生类型和Lyz1淘汰赛小鼠的表型分析.
- 肠道微生物群的16S rRNA测序.
- 血管组织的RNA测序.
- 抗生素治疗和没有细菌的小鼠模型.
主要成果:
- Lyz1 缺乏加剧了血管炎症衰老标志物.
- 在Lyz1淘汰赛小鼠中,肠道微生物群的组成和新陈代谢发生了改变.
- PI3K-Akt信号通路与血管衰老有关.
- 口服LYZ的使用逆转了血管衰老的表型,并恢复了肠道微生物的平衡.
结论:
- LYZ是一种与年龄相关的血管疾病的新生物标志物.
- 肠道微生物群-PI3K-Akt轴代表了血管衰老的有希望的治疗点.
相关概念视频
Inflammatory Response I: Vascular and Cellular
16.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.5K
Key Elements for Plant Nutrition
24.3K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.3K
Key Techniques in Microbiology
2.4K
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
2.4K
Seedless Vascular Plants
67.0K
Seedless Vascular Plants Were the First Tall Plants on Earth
67.0K
Inflammatory Response
16.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.8K
Aging
709
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
709


