全球孤儿药物的视觉研究从图书识别的角度
Xiaoya Wen1, Guangzhi Jin2, Chunxing Wu3
1Department of Pharmacy, The Fourth People's Hospital of GuiYang, Guiyang, Guizhou Province, 550007, People's Republic of China.
Drug design, development and therapy
|May 26, 2025
概括
这种图书统计分析揭示了全球孤儿药物研究趋势. 虽然中国中国.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 生物医学研究生物医学研究
- 卫生政策和管理卫生政策和管理
背景情况:
- 孤儿药物对于罕见疾病至关重要,是制药研发的重要领域.
- 了解全球研究趋势和合作对于提高孤儿药物可访问性和有效性至关重要.
- 图书统计分析提供了一种定量方法,用于绘制科学领域的演变和热点.
研究的目的:
- 从2000年到2024年,系统地分析研究格局和全球孤儿药物开发的新趋势.
- 划出中国与其他国际地区在孤儿药物研究中的相似之处和差异.
- 为未来的研究和孤儿药物领域的战略规划提供有价值的见解和参考资料.
主要方法:
- 从中国国家知识基础设施 (CNKI) 和科学网络数据库中获取的3598篇研究论文进行了图书统计分析.
- 使用微软Office Excel 2017,VOSview 1.6.20和CiteSpace 6.3R2进行数据总结和可视化.
- 检查了研究趋势,合作模式,有影响力的机构和不断变化的研究重点.
主要成果:
- 中国的孤儿药研究显示出持续的上升趋势,而国际研究处于较慢的发展阶段.
- 美国和英国表现出强大的影响力,与成熟的国际合作,而中国显示有限的国际合作.
- 关键的研究领域包括孤儿药物开发和临床应用,越来越关注临床可访问性和监管批准.
结论:
- 孤儿药物研究正在扩大,具有不同的国家和国际轨迹和协作动态.
- 解决临床可访问性和监管途径是一个关键的新兴全球研究重点.
- 这些发现提供了一个全面的概述,以指导未来的研究和政策在孤儿药领域.
相关概念视频
01:02Prescription, Nonprescription and Orphan Drugs
861
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
861
01:26Drug Discovery: Overview
8.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.8K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
185
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
185
01:11Drug Distribution: Overview
329
Drug distribution within the body is a dynamic process involving the movement of a drug in two directions across various compartments: from the bloodstream into tissues (tissue uptake) and from tissues back into the bloodstream (tissue release or redistribution). This process is passive and primarily driven by two variables: the concentration gradient between the bloodstream and the extravascular tissues and the drug's ability to cross the cell membrane.
Initially, the free drug in the...
Initially, the free drug in the...
329
01:19Pharmacovigilance
1.0K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.0K
01:26Targets for Drug Action: Overview
7.6K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
7.6K