在接受bedinvetmab (Librela) 的狗中发生肌肉骨不良事件
Mike Farrell1, Felix W A Waibel2, Ines Carrera3
1Ferguson Veterinary Clinic, Glenrothes, United Kingdom.
Frontiers in veterinary science
|May 26, 2025
概括
与其他骨关节炎药物相比,用bedinvetmab (LibrelaTM) 治疗的狗的肌肉骨不良事件报告 (MSAER) 显着更高. 专家审查表明,有强烈的怀疑与bedinvetmab.link相关的加速关节破坏.
科学领域:
- 兽医药物学 兽医药物学
- 狗的健康 狗的健康
- 药物监督 药物监督 药物监督
背景情况:
- 肌肉骨不良事件 (MSAERs) 是狗骨关节炎管理中的一个问题.
- 贝丁维特马布 (LibrelaTM) 是一种较新的治疗选择,用于治疗狗骨关节炎.
- 对bedinvetmab与已知治疗方法的安全性数据的比较至关重要.
研究的目的:
- 与六种比较药物相比,在用bedinvetmab治疗的狗中进行专家领导的MSAER不成比例分析.
- 评估独立专家对狗子组不良事件数据的判断结果.
主要方法:
- 一项病例控制研究和病例系列分析使用欧洲药物署的EudraVigilance数据库 (2004-2024) 和19只客户拥有的狗的数据进行.
- 一位兽医专家审查了bedinvetmab和比较药物的所有MSAER,测试了关于事件率和药物推出时间的假设.
主要成果:
- 不成比例性分析不支持最初的假设.
- 包括带/肌损伤,多关节炎,骨折和败血性关节炎在内的MSAERs在接受bedinvetmab治疗的狗中报告的频率大约是9倍.
- 一个专家小组一致怀疑bedinvetmab和加速关节破坏之间存在因果关系.
结论:
- 这项研究支持FDA发现,在用bedinvetmab治疗的狗中,肌肉骨不良事件报告率增加.
- 需要进一步调查和对用bedinvetmab治疗的狗进行密切的临床监测.
- 这些发现凸显了对bedinvetmab的风险和药物监管的大规模研究的需要.
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