基于深度学习的抑郁症和喘事件时间分析,使用我们所有人的研究计划
Xueting Wang1,2, Lucila Ohno-Machado1, Jose L Gomez3
1Section of Biomedical Informatics and Data Science.
概括
这项研究在超过239,000人中发现了抑郁症和喘之间的重要联系. 深度学习模型在分析这种关联方面没有超过传统方法.
科学领域:
- 医疗信息学 医疗信息学
- 公共卫生 公共卫生
- 精神病学是一个精神病学.
背景情况:
- 越来越多的人认识到抑郁症和喘之间的关联.
- 使用先进分析模型的大规模回顾性研究是有限的.
研究的目的:
- 用深度学习 (DL) 和传统的统计模型分析抑郁症和喘之间的关联.
- 为了比较DL模型 (DeepSurv,DeepHit) 与后勤回归和Cox比例危险 (CoxPH) 模型的性能.
- 用SHAP值识别影响喘患者抑郁症的关键变量.
主要方法:
- 对239,161名来自我们所有人研究计划的参与者的回顾性队列研究.
- 分析使用了基于DL的模型,物流回归和CoxPH模型.
- 用SHAP值来判断DL模型的可解释性;用c-index评估模型的性能.
主要成果:
- 在喘患者中观察到抑郁症的显著几率比率.
- 考克斯PH模型实现了0.619的c指数,DeepSurv是0.625,而DeepHit是0.596.
- 与CoxPH模型相比,SHAP分析揭示了不同的重要变量,突出了出生时的性别和收入.
结论:
- 强有力的证据支持抑郁症和喘之间存在积极的关系.
- 基于DL的模型在预测准确度 (c指数) 方面没有超过CoxPH模型.
- 出生时的性别和收入是喘患者抑郁症发生的潜在重要因素.
相关概念视频
Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Long-term Depression
3.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.1K
Long-term Depression
33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Asthma-II: Pathophysiology and Classification
4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K


