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双方式溶解微针与纳米颗粒涂层和封装,用于扩展双药物输送

Mingshan Li¹, Akmal H B Sabri^1,2, Nuoya Qin¹

¹School of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK.

Small (Weinheim an der Bergstrasse, Germany)

|May 26, 2025

概括

这项研究引入了双模溶解微针 (DMN) 用于持续同时输送二二甲和甲二甲纳米颗粒,通过单个贴片为骨关节炎提供了改进的治疗方法.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

微针 (MN) 平台面临着由于有限的容量和持续释放要求,在联合提供多种药物方面面临挑战.
骨关节炎的治疗需要有效的,持续的抗炎药物,如迪克洛芬雅克 (DCF) 和德克萨米 (DSP).

研究的目的:

开发和评估双模涂层溶解微针 (DMN) 贴片,用于扩展二二甲和甲纳米颗粒的联合输送.
评估用于骨关节炎治疗的双药装载DMN的通过皮肤透,释放动力学和体内药理动力学.

主要方法:

用DCF纳米粒子在尖端和DSP-PLGA纳米悬浮作为涂层制造DMN.
使用新生猪皮肤进行ex vivo皮肤透研究,以评估DMN的疗效.
在老鼠体内进行的药理动力学研究,以确定药物的血水平,生物可用性和组织分布.

主要成果:

DMN实现了>90%的透到角层,有效地提供DCF和DSP.
在体内研究显示持续DCF血水平72小时 (13.0小时半衰期,80.3%的生物可用性) 和双相DSP释放达到24-30小时 (63.9%的生物可用性) 的峰值.
高度的药物在皮肤和脚组织中维持了72小时,表明局部治疗效果持续了很长时间.

结论:

双通道DMN提供了一个高负载,持续释放的平台,用于微创的双药疗法.
这种方法优化了骨关节炎的治疗,通过一个对患者友好的,单片补丁输送系统来提高患者的遵守性.
开发的DMN技术显示出改善局部药物输送和治疗结果的巨大潜力.

关键词:

这是一种双模式的双模式.德克萨米他是一种狄克洛芬雅克 (Diclofenac) 是一种可怕的药物.微针是一种微针.纳米晶体是一种纳米晶体.骨关节炎是一种关节炎.通过皮肤传递的传递.

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