可光切换的抗微生物金属螺旋体
Changhao Liu1, Mi Li2, Xinyu Wang1
1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, China.
Angewandte Chemie (International ed. in English)
|May 26, 2025
概括
状金属螺旋复合体与交叉基单元显示可逆的光化学转换. 辐射通过破坏细胞膜来增强它们的抗菌活性.
科学领域:
- 超分子化学 超分子化学
- 协调化学 协调化学
- 摄影化学的使用.
背景情况:
- 状子组件的自我组装使得复杂的分子架构的创建成为可能.
- 金属超分子系统为各种应用提供可调节的性能.
- 亚单位以其光响应性行为而闻名.
研究的目的:
- 为了合成和描述光学纯粹的性金属螺旋体物种.
- 为了研究这些螺旋复合物的光化学转化.
- 评估不同状态的抗菌活性,了解它们的作用机制.
主要方法:
- 使用 Zn 和 Fe (II) 离子自组合的基拉尔子组件.
- 光谱技术 (紫外线,圆形二重化,核磁共振).
- 进行X射线晶体学和密度函数理论 (DFT) 计算.
- 抗菌检测 (MIC确定) 和细胞透性测试.
- 电子显微镜用于可视化细胞效应.
主要成果:
- 成功合成了光学纯净的合金属螺旋复合体,其中包含了特兰萨索单元.
- 在紫外线照射 (365 nm) 后,观察到一个高度可逆的,逐步的光化学转化到一个全cis状态.
- 在整个光化学转化过程中保持了结构完整性和光学纯度.
- 全转录状态显示对格拉姆阳性细菌的活性低至中等,而全状状态显示最小抑制度 (MIC) 降低了多达八倍.
- 作用机制涉及膜破坏,由于其紧的结构,全-cis状态更有效.
结论:
- 状金属螺旋复合体可以经历受控的光化学转换.
- 亚博单元的光异构化显著调节了这些超分子系统的抗菌疗效.
- 所有cis光产品的增强活性归因于其独特的超分子构造,促进了膜破坏.
相关概念视频
01:23Antimicrobial Proteins
6.6K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
6.6K
01:28Antimicrobial Effectiveness
179
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
179