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Updated: Sep 20, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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在完全化学稳定的siRNA中对七个脊椎和肋骨修饰的位置特异性耐受性进行系统评估

Daniel O'Reilly1, Raymond Furgal1, Vignesh Hariharan1

  • 1RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

Nucleic acid therapeutics
|May 26, 2025
PubMed
概括

这项研究系统地评估了短干扰RNAs (siRNAs) 中各种化学修饰的耐受性. 研究结果显示,siRNA的疗效在很大程度上取决于修饰类型,序列和位置,指导未来的治疗开发.

关键词:
化学修饰 化学修饰 化学修饰基因沉默是对基因进行沉默的方法.氧核酸类的部分.siRNA 是一个RNA.

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