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一个集成的AI-PBPK平台,用于预测人体内药物命运和组织分布在人类和物种间的推断

Wei Wang1, Nannan Wang1, Yiyang Wu1

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.

Clinical pharmacology and therapeutics
|May 26, 2025
PubMed
概括

这项研究引入了一个AI-PBPK平台,仅使用分子结构来预测体内的药物行为. 这种方法通过有效估计药物动力学特征并指导临床试验候选人选择来加速药物开发.

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