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一个基于数据的模型,用于估计运动期间呼吸诱导的干内血液转移

Gabriele Corigliano¹, Barbara Uva², Bengt Kayser²

¹Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.

Journal of applied physiology (Bethesda, Md. : 1985)

|May 26, 2025

概括

这项研究引入了一种电气模型,用于量化呼吸期间的干内血液转移 (Vbs_IT). 该模型准确地估计了腹部和胸部之间的血流变化,揭示了特定呼吸模式期间的显著变化.

科学领域:

心血管生理学心血管生理学
呼吸机械学呼吸机械
数学建模的数学建模

背景情况:

呼吸道肌肉压力波动导致身体部分之间的血液转移 (Vbs).
之前的方法量化了Vbs,但没有在腹部和胸部之间进行体内血液转移 (Vbs_IT).
量化Vbs_IT对于理解心肺功能至关重要.

研究的目的:

开发和验证一个电气模型来估计每次呼吸的Vbs.
在各种呼吸模式和呼气流量限制期间量化Vbs_IT.
探索Vbs_IT和跨隔膜压力之间的关系.

主要方法:

开发了心血管系统的电模型来估计Vbs_IT.
该模型使用健康参与者在运动期间的实验数据进行了验证.
参与者进行了自发呼吸 (CTRL),腹部 (AB),胸 (RC) 呼吸,并经历了呼吸流量限制 (EFLe).

主要成果:

该模型准确地复制了实验观察到的每次呼吸的Vbs波动.
在自发呼吸过程中,Vbs_IT显示出最小的变化,但在AB,RC和EFLe过程中显著增加.
内呼吸Vbs_IT与跨隔膜压力密切相关,反映了液压压力效应.

结论:

开发的电气模型提供了Vbs_IT的定量估计.
异常的呼吸模式和排气流量限制显著改变了体内血液的分布.
这种模型是研究心肺呼吸系统病理生理学的宝贵工具,在各种条件下.

关键词:

在OEP上,OEP是OEP.血液的转移是因为血液的转移.呼吸呼吸呼吸呼吸运动就是炼身体.静脉回归是一种回归.

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