现有的物质使用障碍对长期使用阿片类药物和手术后并发症的影响
Philong Nguyen1, Joshua E Lewis2, Isabelle J Carroll3
1John Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, United States.
概括
患有物质使用障碍 (SUD) 的患者在烧伤后经历了更糟糕的结果,包括长期使用阿片类药物和伤口并发症. 酒精使用障碍是阿片类药物使用和并发症的最高风险.
科学领域:
- 烧伤手术的结果
- 药物使用障碍研究 药物使用障碍研究
- 手术后护理和疼痛管理
背景情况:
- 以前存在的物质使用障碍 (SUD) 与烧伤患者的不良结果有关.
- 不同物质对术后阿片类药物使用和并发症的具体影响尚不清楚.
研究的目的:
- 为了比较酒精,大麻和烟草使用障碍对阿片类药物使用的影响以及烧伤患者的术后结果.
- 分析与这些SUD相关的风险,并确定物质之间的差异.
主要方法:
- 使用TrinetX数据库进行回顾性队列研究.
- 包括烧伤患者 (≥18岁) 具有先前存在的酒精,大麻或烟草使用障碍.
- 倾向性得分匹配以根据人口统计,心理健康,疼痛综合征和烧伤严重程度将SUD队列与非SUD控制队列进行比较.
主要成果:
- 患有SUD的患者在3个月和12个月的烧伤后显著增加了长期使用阿片类药物,伤口感染和伤口愈合障碍的风险.
- 所有SUD群体都经历了术后疼痛的风险增加.
- 酒精使用障碍与阿片类药物使用和并发症的最大增加有关;烟草使用障碍显示了最高的伤口破坏率.
结论:
- 烧伤患者具有先前存在的SUD面临着长期使用阿片类药物和术后并发症的显著更高风险.
- 药物使用障碍复杂化烧伤恢复,需要量身定制的管理策略.
- 酒精和烟草使用障碍存在明显的风险,酒精与更大的阿片类药物使用和并发症有关,烟草与更高的伤口破坏有关.
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