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评估丹麦肥胖年轻人的糖尿病前期和心脏代谢风险
Anna Katrine Gaul1, Louise Aas Holm1,2, Torben Hansen2
1Department of Paediatrics, The Children's Obesity Clinic, Accredited European Centre for Obesity Management, Holbaek Hospital, Part of Copenhagen University Hospital, Holbaek, Denmark.
概括
不同的糖尿病前期定义会影响肥胖年轻人的患病率和心脏代谢风险. 联合的禁食血葡萄糖 (FPG) 或糖基化血红蛋白 (HbA1c) 定义确定了大多数病例,突出了这一群体的重大健康风险.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
背景情况:
- 糖尿病前期是儿童肥胖症中日益关注的一个问题.
- 准确的诊断标准对于识别有风险的年轻人至关重要.
- 不同的诊断方法可能会产生不同的流行率估计和风险关联.
研究的目的:
- 使用四个定义 (FPG,HbA1c,FPG或HbA1c,FPG和HbA1c) 来比较糖尿病前期的患病率.
- 评估这些定义与丹麦儿童和青少年肥胖的心脏代谢风险因素之间的关联.
主要方法:
- 对2849名接受三级肥胖治疗的儿童和青少年 (5-18岁) 的横截面研究.
- 对人体测量,血压和血液样本进行分析,以确定糖尿病前期状态.
- 对高血压,脂质失调,腹部肥胖,高ALT和严重肥胖 (BMI SDS ≥99百分位) 的几率比率的计算.
主要成果:
- 糖尿病前期患病率有显著差异:12.8% (FPG),6.6% (HbA1c),17.2% (FPG或HbA1c) 和2.2% (FPG和HbA1c).
- FPG或HbA1c定义确定了最高的患病率,并与更大的心脏代谢风险负担有关.
- 根据FPG定义的糖尿病前期与高血压/腹部肥胖相关;根据HbA1c定义的糖尿病前期与脂质不良/高ALT/严重肥胖相关.
结论:
- 根据FPG或HbA1c的定义,可以捕捉到大量患有糖尿病前期的年轻人,他们的心脏代谢风险很大.
- 没有一个诊断测试是普遍优越的;每个定义都突出了不同的风险概况.
- 这些发现强调了需要仔细考虑诊断标准在儿科糖尿病前期管理.
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