脑源性神经缩因子与与疾病相关的营养不良患者的萨科佩尼亚有关
Daniel de Luis1, David Primo1, Olatz Izaola1
1Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School, Department Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Annals of nutrition & metabolism
|May 26, 2025
概括
低水平的脑衍生性神经营养因子 (BDNF) 与肉症有关,这是肌肉质量损失的情况,在患有疾病相关营养不良 (DRM) 的患者中. 较高的BDNF水平可能表明患上萨尔科佩尼亚的风险降低.
科学领域:
- 生物化学 生物化学
- 老年学是一门学科.
- 临床营养学 临床营养学
背景情况:
- 萨科佩尼亚的特点是逐渐减轻肌肉质量.
- 脑衍生神经营养因子 (BDNF) 可能会在慢性病中保护人免受缩症.
- 在患有疾病相关营养不良 (DRM) 的个体中,BDNF在肉症中的作用需要进一步调查.
研究的目的:
- 探索在DRM患者中循环BDNF水平和肉症之间的关联.
- 为了确定BDNF水平是否可以预测这个人群中肉症的风险.
主要方法:
- 纳入了160名DRM患者 (根据GLIM标准诊断).
- 测量包括人体测量,肌肉质量 (超声波,BIA),手握强度,生物化学参数,饮食摄入量和血清BDNF水平.
- 使用后勤回归分析,根据BDNF水平,对共变量进行调整,来评估肉类的风险.
主要成果:
- 34.4%的患者被归类为 Sarcopenic.
- 麻症患者的肌肉质量指数和强度明显下降.
- 与非sarcopenic患者相比,sarcopenic患者的循环BDNF水平明显较低 (p=0.01).
- 在调整后,较高的BDNF水平与低的肉症风险相关 (OR=0.16,p=0.03).
结论:
- 低血清BDNF水平与DRM患者的肉症有关.
- 在营养不良的个体中,BDNF可能会起到保护性作用,防止肉类的发展.
- 需要进一步的研究来阐明BDNF在肉症中的治疗潜力.
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