阿斯特雷乌索尔A-E:来自野生食用Astraeus asiaticus的拉诺斯坦型三烯
Jedsada Maliwong1, Nitirat Chimnoi2, Natsajee Nualkaew3
1Chulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok, 10210, Thailand; Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.
Phytochemistry
|May 26, 2025
概括
研究人员发现了来自亚洲 (Astraeus asiaticus) 的五种新型兰诺斯坦三烯,阿斯特雷索尔A-E. 两个化合物代表了与乙烯胺结合的兰三烯的第一个天然来源.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 有机化学 有机化学
背景情况:
- 亚洲 (Astraeus asiaticus) 是各种化学化合物的来源.
- 拉诺斯坦三烯是一种具有各种生物活性的重要自然产品.
研究的目的:
- 从Astraeus asiaticus的果实体中分离和描述新型化合物.
- 为了研究这种真菌物种中兰三烯的化学多样性.
主要方法:
- 使用色谱技术分离化合物.
- 使用广泛的光谱分析阐明结构,包括1D和2DNMR.
- 对已知化合物的立体化学进行修订.
主要成果:
- 确定了五种新的lanostane三烯,命名为astrraeusols AE.
- 阿斯特雷奥索尔D和E是新型的兰诺斯坦三烯,通过胺键与乙烯胺结合.
- 在C-25的立体化学配置的artabotryolC2修订了从25R到25S.
结论:
- 这项研究扩展了已知的兰诺斯坦三烯的化学结构.
- 亚洲 (Astraeus asiaticus) 是发现新型天然产品的宝贵来源.
- 鉴定乙烯胺相关的三烯为天然产品生物合成提供了新的见解.
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