以网络药理为指导,确定兰口服液中生物活性等效组合成分,用于治疗急性喉炎
Meng-Yuan Wang1, Heng-Li Zhao1, Yu-Nuo Fan1
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China.
Journal of ethnopharmacology
|May 26, 2025
概括
兰口服液 (LQL) 有效治疗急性喉炎. 通过网络药理学识别的生物活性等效组合成分 (BECC) 通过通过TLR4/NF-κB通路减少炎症表现出类似的疗效.
科学领域:
- 草药研究 草药研究
- 网络药理学 网络药理学
- 药理学机制 药理学机制
背景情况:
- 兰口服液 (LQL) 是一种治疗急性喉炎的传统草药.
- 它的活性成分和作用机制需要进一步的科学阐明.
- 了解LQL的药理学可以提高其临床应用.
研究的目的:
- 使用网络药理学识别LQL的生物活性等效组合成分 (BECC).
- 研究BECCs在治疗急性炎中的治疗机制.
- 验证关键成分的抗炎作用和协同作用.
主要方法:
- 网络药理学被用来构建一个组件-疾病-目标网络.
- 根据网络分析确定了候选BECC.
- 在体外和体内实验中评估了BECCs的疗效.
- 进行了信号通路验证和关键化合物的协同效应分析.
主要成果:
- 网络药理学确定了25种潜在的活性成分和35个点,涉及治疗急性炎.
- 13种化合物被确定为BECC,其疗效与LQL.相似.
- BECCs降低了氧化,炎症因子 (IL-6,IL-1β,TNF-α) 和TLR4/NF-κB通路蛋白.
- 柏柏林和日尼胺显示出显著的协同抗炎作用.
结论:
- LQL的BECC具有与急性喉炎的原始配方相似的治疗效果.
- 抗炎机制涉及TLR4/NF-κB信号通路的调节.
- 各种成分之间的协同作用有助于LQL的药理活性,支持其临床使用.
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