牛冠状病毒在哈萨克斯坦牛群中的发生情况和流行病学
Yuliya V Perfilyeva1, Andrey V Zhigailov1, Angelina A Malysheva1
1Almaty Branch of the National Center for Biotechnology, National Holding "QazBioPharm", 14 Zhahanger St., Almaty 050054, Kazakhstan.
Veterinary journal (London, England : 1997)
|May 26, 2025
概括
牛冠状病毒 (BCoV) 在哈萨克斯坦广泛传播,在牛中血清流行率很高. 这项研究确定了风险因素,并证实了流行性循环,强调了需要控制计划的必要性.
科学领域:
- 兽医病毒学 兽医病毒学
- 流行病学 流行病学
- 分子生物学分子生物学
背景情况:
- 牛冠状病毒 (BCoV) 是一种重要的病原体,导致牛的肠道和呼吸系统疾病.
- 在哈萨克斯坦,一个大型畜牧生产国,BCoV的流行病学状况以前是未经记录的.
研究的目的:
- 确定哈萨克斯坦BCoV的全国流行率和流行病学特征.
- 确定与哈萨克斯坦牛群中BCoV感染相关的风险因素.
- 为了描述循环BCoV菌株的遗传谱系.
主要方法:
- 一项全国性的横截面研究,涉及来自17个地区的390个农场的2237头牛.
- 使用ELISA检测BCoV抗体和RT-PCR检测鼻腔和直肠拭子中的病毒RNA的血清检测.
- 血凝素/雌激酶和尖端基因的基因分析,以及风险因素评估的单变量和多变量统计建模.
主要成果:
- 在全国范围内观察到BCoV的高动物 (88.2%) 和群体 (89.6%) 血清流行率.
- 在2.4%的动物和7.8%的群体中检测到BCoV泄漏;血清流行率因地区而异.
- 感染风险与牛群密度,农场规模和后院牛群比例有关,但不是年龄,性别或品种.
- 遗传学分析将哈萨克斯坦BCoV菌株置于GIIa组内.
结论:
- 牛类冠状病毒在哈萨克斯坦是流行病,在全国范围内有很高的血清流行率.
- 诸如牛群密度和农场规模等流行病学因素影响BCoV传播.
- 这些发现强调了制定和实施国家BCoV控制战略的必要性.
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