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具有上呼吸道炎症和嗅觉功能障碍的小鼠模型嗅觉上皮质的功能和形态变化

Shin Hyuk Yoo¹, Jun-Sang Bae¹, Reiza Ventura¹

¹Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.

Clinical and experimental otorhinolaryngology

|May 26, 2025

概括

这项研究比较了过敏性鼻炎,慢性鼻炎和药物诱导的厌氧症的小鼠模型. 与其他模型相比,Anosmia模型显示显著的嗅觉功能障碍和嗅觉感官神经元减少.

科学领域:

嗅觉神经科学是一种神经科学.
免疫学免疫学免疫学
动物建模动物建模

背景情况:

过敏性鼻炎 (AR),慢性鼻炎 (CRS) 和药物诱导的厌氧是影响上呼吸道和嗅觉的疾病.
建立可靠的小鼠模型对于理解嗅觉功能障碍和开发有针对性的疗法至关重要.

研究的目的:

评估和比较不同的AR,CRS和药物诱导的厌氧症的小鼠模型中的行为和组织学结果.
为了确定与每个条件相关的特征性嗅觉缺陷和神经元变化.

主要方法:

建立了六种小鼠模型:对照模型,卵蛋白 (OVA) 诱导的AR,OVA/多蛋白 (I:C) 诱导的鼻炎,OVA/Staphylococcus肠毒素B诱导的CRS,以及两种阿诺斯米亚模型 (ZnSO4和3-methylindole).
嗅觉功能使用开放式寻找食物和T迷宫测试进行评估,并通过EthoVision XT进行行为分析.
免疫光染色评估了嗅觉感官神经元 (OSN) 和基底细胞.

主要成果:

与所有其他小组相比,Anosmia模型的食物寻找时间显著延长.
鼻炎模型显示,与对照组和CRS组相比,食物寻找时间增加.
组织学分析显示,在CRS和阿诺斯米亚模型中,成熟和不成熟的OSN减少,在3-甲基英多尔模型中具有特定的基底细胞标记物变化.

结论:

在各种上呼吸道炎症和厌氧症小鼠模型中,嗅觉功能和组织学存在显著差异.
这些发现为未来使用已建立的小鼠模型进行嗅觉研究提供了宝贵的参考.

关键词:

行为, 动物, 动物的行为嗅觉障碍嗅觉障碍嗅觉障碍嗅觉受体神经元嗅觉受体神经元鼻炎,过敏性鼻炎,过敏性鼻炎是一种鼻炎.

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