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调查母亲年龄与脑发病率之间的关联:一个元分析

Jae Meen Lee^1,2, Kyoungjune Pak^2,3

¹Department of Neurosurgery and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

|May 26, 2025

概括

出生于18岁或以下母亲的孩子面临脑 (CP) 的风险增加. 35岁或以上的母亲的满期分娩也可能会提高CP风险,为公共卫生规划提供信息.

科学领域:

神经学神经学
公共卫生公共卫生
流行病学流行病学

背景情况:

大脑麻 (CP) 是一组来自早期脑损伤的运动障碍.
母亲年龄是CP的已知风险因素,但研究结果不一致,特别是在晚年母亲年龄方面.
以前的元分析往往缺乏妊娠年龄分层或最近的研究.

研究的目的:

提供对产妇分娩年龄和CP风险之间的关联的最新评估.
完善年龄组分类,并根据妊娠年龄进行子组分析.
为风险评估和公共卫生规划提供信息.

主要方法:

在Embase,PubMed和Medline数据库中进行系统搜索 (截至2024年3月).
包括12项研究,根据母亲的年龄对比CP病例和对照.
使用R统计软件进行的元分析,检查在母年龄组 (≤18,≤25,≥35,≥40岁) 中对CP的几率比率 (OR).

主要成果:

年轻的母亲年龄 (≤18岁) 显著增加了CP风险 (OR=0.1374,P<.0001).
25岁和35岁左右的母亲年龄组显示出混合风险.
出生于35岁及以上的母亲的产期婴儿患CP的几率更高 (OR=0.9198,P=.0023).

结论:

18岁或更年轻的母亲所生孩子的CP风险较高.
35岁或以上的母亲的满期分娩也可能与CP风险增加有关.
结果可以指导风险评估和预防CP的公共卫生策略.

关键词:

脑性麻脑性麻是一种影响力影响力影响力影响力母亲的年龄孕产妇的年龄赔率比率赔率比率的比率.

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