在乳腺癌幸存者的随机体育活动干预试验中,加速器测量误差是无差异的,但减弱了干预效应
Laura Q Rogers1,2, Douglas Midthune3, Kevin Dodd3
1Division of General Internal Medicine and Population Science, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, 1720 2ndAve S, MT 614, Birmingham, AL 35294-4410, Birmingham, AL, USA. lqrogers@uabmc.edu.
概括
癌症幸存者的体力活动干预措施可以使用偏差纠正的加速度计数据更准确地测量. 这项研究表明,计算测量误差如何提高身体活动对癌症幸存者的估计影响.
科学领域:
- 运动科学 运动科学
- 生物统计学 生物统计学
- 癌症的生存率 癌症的生存率
背景情况:
- 身体活动对于癌症幸存者的健康至关重要,但许多人仍然保持不活跃.
- 随机对照试验 (RCT) 对于评估身体活动干预措施至关重要.
- 在自由生活条件下精确测量身体活动是RCT的一个重大挑战.
研究的目的:
- 为了评估乳腺癌幸存者的3个月体育活动干预措施.
- 为了应对基于加速度计的身体活动评估中的测量误差在RCT中的挑战.
- 为了纠正因加速度计测量错误引起的干预效应估计偏差.
主要方法:
- 这是一项随机对照试验,涉及316名乳腺癌幸存者.
- 通过部佩戴的加速度计测量的主要结果.
- 一项子研究 (n=106) 用双重标记的水和间接热量计来测量无偏的能源支出.
- 使用线性混合测量误差模型来纠正加速度计数据.
主要成果:
- 加速度计偏差与真正的体力活动能量消耗 (PAEE) 和基线BMI有关.
- 对PAEE进行校正的干预效应为77千卡/天,而未经校正的干预效应为48千卡/天.
- 经过纠正的模型显示PAEE增加了20%,而未经纠正的模型则增加了14%.
- 测量误差在治疗臂之间没有发现差异.
结论:
- 加速度计的测量误差可能会低估RCT中身体活动干预的真实效果大小.
- 具有公正措施的子研究对于纠正测量错误至关重要.
- 对身体活动的准确评估是验证癌症幸存者的干预措施的关键.
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