甲状腺和肝脏之间的代谢和功能交叉对话
Chiaw-Ling Chng1, George Boon Bee Goh2, Paul Michael Yen3,4,5
1Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
概括
甲状腺疾病影响肝脏代谢,导致诸如代谢功能障碍相关的脂肪性肝病 (MASLD) 等疾病. 了解这种甲状腺-肝脏轴对于管理代谢和肝脏疾病至关重要,而甲状腺模拟药物显示出有前途.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢生理学 代谢生理学
背景情况:
- 肝脏和甲状腺密切影响对方的功能和代谢平衡.
- 甲状腺功能障碍 (低甲状腺和高甲状腺症) 影响肝脏的碳水化合物和脂肪代谢,影响葡萄糖,胆固醇和甘油三水平.
- 甲状腺功能低下症和肝内甲状腺功能低下症都与高胆固醇和代谢功能障碍相关的脂肪性肝病 (MASLD) 有关.
研究的目的:
- 审查甲状腺疾病和治疗对肝脏生理学,新陈代谢和病理学的影响.
- 为了检查肝脏疾病如何影响甲状腺功能.
- 总结关于甲状腺激素在代谢综合征,高脂血症和MASLD中的作用的证据,以及甲状腺模拟剂在治疗中的潜力.
主要方法:
- 临床和实验研究的文献综述.
- 分析甲状腺功能与肝脏代谢过程之间的相互作用.
- 综合当前关于对代谢疾病的甲状腺素效果的研究.
主要成果:
- 甲状腺激素 (THs) 显著影响肝脏代谢,并与代谢综合征,高脂血症和MASLD有关.
- 肝功能障碍可以改变甲状腺激素度及其外周作用.
- 甲状腺模拟剂代表了对像MASLD这样的代谢疾病的潜在治疗策略.
结论:
- 识别甲状腺-肝脏轴对于管理患有同时存在甲状腺和肝脏疾病的患者至关重要.
- 关于甲状腺激素在肝脏中的作用的新兴见解正在完善对代谢疾病发病的理解.
- 甲状腺模拟剂为MASLD提供了一种新的治疗途径,强调甲状腺与肝脏关系的重要性.
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