相关实验视频

Updated: Sep 20, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

基于微生物群的干预措施对儿童和青少年的抑郁和焦虑的影响 - 一个系统性审查

Jiayu Hu¹, Yan Zhang², Chuwen Liu¹

¹Department of Population, Policy & Practice, Childhood Nutrition Research Group, UCL Great Ormond Street Institute of Child Health, London, UK.

Journal of pediatric gastroenterology and nutrition

|May 27, 2025

概括

肠道微生物群干预措施,如益生菌和食补充剂,显示出降低儿童和青少年抑郁和焦虑的潜力. 然而,由于研究的局限性,需要更多的研究.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
儿科儿科儿科

背景情况:

患有某些疾病的儿童和青少年可能会经历抑郁和焦虑.
基于肠道微生物群的干预措施正在探索心理健康症状管理.

研究的目的:

系统地审查关于肠道微生物群干预儿童和青少年抑郁和焦虑的证据.
评估益生菌,益生菌和食补充剂的有效性.

主要方法:

对儿童和青少年 (3-19岁) 随机对照试验 (RCT) 的系统综述.
搜索了PsycINFO,Medline,科学网;使用RoB 2评估了偏差风险.
包含的RCT中发现的结果的定性总结.

主要成果:

包括10个带有408名参与者的RCT.
益生菌和食补充剂在3项研究中显示出有效性;7项研究发现没有显著影响.
没有证据支持益生菌的有效性;偏差风险在不同研究中各不相同.

结论:

益生菌和食补充剂显示出降低儿童群体抑郁和焦虑的潜力.
目前的证据受到测量问题,异质性和小样本大小的限制.
需要进一步的精心设计的研究来确认疗效.

关键词:

我们的肠道微生物组.心理健康心理健康精神病生物制剂精神病生物制剂年轻人年轻人年轻人

更多相关视频

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

相关概念视频

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...